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Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; Cholesterol, high-density lipoprotein (HDL), serum. Mayo Clinic Laboratories. https://www.mayocliniclabs.com/test-catalog/overview/8429#Clinical-and-Interpretive. Accessed March 16, 2022. Gradually work to a high dose: Start with a low dose of niacin and slowly increase the amount over time. This may help you adjust to the niacin flush so that it is not as unpleasant. For example, you can take 100 mg of niacin twice daily, then double the amount each week until you reach the recommended dose. If you are allergic to Niacin Flush Free ( inositol niacinate); any part of Niacin Flush Free (inositol niacinate); or any other drugs, foods, or substances. Tell your doctor about the allergy and No Flush Niacin 500 mg is to be taken as 1-2 a day and comes in vegetable capsule form, making it easy to absorb. This special no flush formula with Vitamin B3 contributes to:
According to self-reported data from the 2013–2014 NHANES, 21% of all individuals age 2 and older took a dietary supplement containing niacin [ 16]. The proportion of users increased with age from 8% of those age 12–19 years to 39% of men and 40% of women age 60 and older. Supplement use doubled or tripled total niacin intakes compared with intakes from diet alone. According to data from the 2003–2006 NHANES, 10% of all individuals age 2 and older who took dietary supplements had total niacin intakes that reached or exceeded the UL [ 19]. Niacin Deficiency As mentioned above, to avoid unwanted symptoms, including flushing, some people opt for extended-release or long-acting niacin. Niacin has been a useful ingredient to lower LDL and triglycerides for decades. Although it is not a source to entirely rely on, it has shown impressive results. A clinical study for effect niacin has on cholesterol levels show a decrease in bad cholesterol (LDL) by up to 20%. Ease into it. Some experts recommend starting with a smaller dose like 500 mg and then increasing to 1,000 mg gradually over the course of 2 months, before finally increasing to 2,000 mg. This strategy could bypass flush entirely ( 5).Take it with food: Although niacin is water-soluble, eating an apple or taking niacin in the morning right after breakfast can help slow down niacin absorption, easing the intensity of a niacin flush. There are major risks to a niacin flush that should be seriously considered before choosing it as a line of treatment. Niacin also decreases oxidative stress and inflammation, a common cause of artery conditions such as atherosclerosis. Carcinoid syndrome is caused by slow-growing tumors in the gastrointestinal tract that release serotonin and other substances. It is characterized by facial flushing, diarrhea, and other symptoms. In those with carcinoid syndrome, tryptophan is preferentially oxidized to serotonin and not metabolized to niacin [ 2]. As a result, the body has less available tryptophan to convert to niacin. Niacin and Health Cardiovascular disease
Because absorbability can significantly vary depending on the form of niacin used, it’s a good idea to ask your healthcare provider what form would be best for your specific health needs. summaryCholesterol medications. American Heart Association. https://www.heart.org/en/health-topics/cholesterol/prevention-and-treatment-of-high-cholesterol-hyperlipidemia/cholesterol-medications. Accessed March 1, 2022. Jacobson TA. A "hot" topic in dyslipidemia management - "How to beat a flush": Optimizing niacin tolerability to promote long-term treatment adherence and coronary disease prevention. Mayo Clin Proc. 2010;85(4):365-79. However, one study placed mice on a high-fat diet or a control diet, and after six weeks they were given either vehicle or niacin treatments for five weeks. The researchers concluded, “Niacin treatment attenuates obesity-induced adipose tissue inflammation through increased adiponectin and anti-inflammatory cytokine expression and reduced pro-inflammatory cytokine expression in a niacin receptor-dependent manner.” ( 13) 6. Helps Treat Pellagra
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